Abnormally low level of SMN protein linked to movement problems in spinal muscular atrophy

Abnormally low level of SMN protein linked to movement problems in spinal muscular atrophy

News-Medical.net | April 12, 2012

An abnormally low level of a protein in certain nerve cells is linked to movement problems that characterize the deadly childhood disorder spinal muscular atrophy, new research in animals suggests.

Spinal muscular atrophy, or SMA, is caused when a child’s motor neurons – nerve cells that send signals from the spinal cord to muscles – produce insufficient amounts of what is called survival motor neuron protein, or SMN. This causes motor neurons to die, leading to muscle weakness and the inability to move.

Though previous research has established the disease’s genetic link to SMN in motor neurons, scientists haven’t yet uncovered how this lack of SMN does so much damage. Some children with the most severe form of the disease die before age 2.

A research team led by Ohio State University scientists showed in zebrafish that when SMN is missing – in cells throughout the body as well as in motor neurons specifically – levels of a protein called plastin 3 also decrease.

When the researchers added plastin 3 back to motor neurons in zebrafish that were genetically altered so they couldn’t produce SMN, the zebrafish regained most of their swimming abilities – movement that had been severely limited by their reduced SMN. These findings tied the presence of plastin 3 – alone, without SMN – to the recovery of lost movement.

Click HERE or on the image below to read more…

Advertisements

2 Responses to Abnormally low level of SMN protein linked to movement problems in spinal muscular atrophy

  1. seo services,…

    […]Abnormally low level of SMN protein linked to movement problems in spinal muscular atrophy « SMAHeadlines.com[…]…

  2. Write more, thats all I have to say. Literally, it
    seems as though you relied on the video to make your
    point. You clearly know what youre talking about, why waste your
    intelligence on just posting videos to your weblog
    when you could be giving us something enlightening to read?

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: